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Title   진행성 위암 환자에서 5 - Fluorouracil , Etoposide 및 Cisplatin ( FEP ) 3 제 복합화학요법의 치료효과 ( Treatment of Advanced Gastric Cancer with 5 - Fluorouracil , Etoposide and Cisplatin ( FEP ) )
Publicationinfo   1992 Jan; 024(05): 702-708.
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Abstract   We conducted a pase II trial of 5-fluoruracil(S-FU), etoposide(VP-l6) and cisplatin in previously untreated patients with metastatic or recurrent gastric adenocarcinoma. Thirty-six patients entered on study from December 1989 to July 1991. The treatment regi- men consisted of a 12 hr continuous infusion of 5-FU(800 mg/m(2)/day) for 5 consecutive days, a bolus iv of VP-16(70mg/m'/day) and cisplatin(25 mg/(2)m/day) for a consecutive days respectively. Treatment was repeated every 3 weeks. Among 30 evaluable patients, 1 patient(3%) achieved a complete response and 9 patients(30%) partial responses, giving an overall response rate of 33%. The median duration of response was 4 months. The median survival for responders was 11 months. Toxicities were common and included bone marrow suppression, nausea and vomiting, alopecia and peripheral neuropathy. In conclusion, a combination chemotherapy with FEP regimen in patients with advanced gastric cancer seems to be comparable to other chemotherapy regimens in efficacy and toxicity.
저 자   장정순(Joung Soon Jang),임영혁(Young Hyuk Im),윤성수(Sung Soo Yoon),이재용(Jae Yong Lee),허대석(Dae Seog Heo),방영주(Yung Jue Bang),김노경(Noe Kyeong Kim)